BAFFR/TNFRSF13C Polyclonal Antibody

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- 宿主: Rabbit
- 反应性: Rat
- 应用性: WB
Verified Samples |
Verified Samples in WB: Rat thymus |
Dilution | WB 1:500-1:1000 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant Human BAFFR/TNFRSF13C protein expressed by Mammalian |
Abbre | BAFFR/TNFRSF13C |
Synonyms | B-cell-activating factor receptor, BAFF receptor (BAFF-R), BAFFR, BLyS receptor 3, BR3, TNFRSF13C, Tumor necrosis factor receptor superfamily member 13C |
Swissprot | |
Calculated MW | 19 kDa |
Observed MW | 38-50 kDa |
Cellular Localization | Membrane |
Tissue Specificity | Highly expressed in spleen and lymph node,and in resting B-cells Detected at lower levels in activated B-cells,resting CD4+ T-cells,in thymus and peripheral blood leukocytes. |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
Purification Method | Antigen Affinity Purification |
Research Areas | Signal Transduction, Stem Cells |
Conjugation | Unconjugated |
Background | Tumor necrosis factor receptor superfamily,member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen,is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17),transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. BAFF R is highly expressed in spleen,lymph node and resting B cells. It is also expressed at lower levels in activated B cell,in resting CD4+ T cells,in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly,A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells,suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. |
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