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BAFFR/TNFRSF13C Polyclonal Antibody

BAFFR/TNFRSF13C Polyclonal Antibody
  • BAFFR/TNFRSF13C Polyclonal Antibody
  • BAFFR/TNFRSF13C Polyclonal Antibody

Price: ¥2100.00 ¥800.00

Size:
100 μL 25 μL
  • 宿主: Rabbit
  • 反应性: Rat
  • 应用性: WB
Verified Samples
Verified Samples in WB: Rat thymus
Dilution
WB 1:500-1:1000
Clonality
Polyclonal
Isotype
IgG
Immunogen
Recombinant Human BAFFR/TNFRSF13C protein expressed by Mammalian
Abbre
BAFFR/TNFRSF13C
Synonyms
B-cell-activating factor receptor, BAFF receptor (BAFF-R), BAFFR, BLyS receptor 3, BR3, TNFRSF13C, Tumor necrosis factor receptor superfamily member 13C
Swissprot
Calculated MW
19 kDa
Observed MW
38-50 kDa
Cellular Localization
Membrane
Tissue Specificity
Highly expressed in spleen and lymph node,and in resting B-cells Detected at lower levels in activated B-cells,resting CD4+ T-cells,in thymus and peripheral blood leukocytes.
Concentration
1 mg/mL
Storage
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer
PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4
Purification Method
Antigen Affinity Purification
Research Areas
Signal Transduction, Stem Cells
Conjugation
Unconjugated
Background
Tumor necrosis factor receptor superfamily,member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen,is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17),transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. BAFF R is highly expressed in spleen,lymph node and resting B cells. It is also expressed at lower levels in activated B cell,in resting CD4+ T cells,in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly,A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells,suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
Western blot with BAFFR/TNFRSF13C Polyclonal antibody at dilution of 1:1000.lane 1:Rat thymus
E-AB-1003 Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) 500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043 Streptavidin(peroxidase/HRP conjugated) 500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1194 HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed 500 μL , 120 μL , 1 mL
E-IR-R304A Western Blot Detection Kit 50 Assays
E-IR-R304B High Accuracy and Absorbability Western Blot Detection Kit 50 Assays


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