BAX Polyclonal Antibody

Verified Samples in WB:MCF-7,A549,HepG2,SH-SY5Y,C2C12,NIH-3T3,Raw264.7,C6

Polyclonal

IgG

Recombinant Human BAX Protein expressed by E.coli

BAX

Apoptosis regulator BAX;Bcl-2-like protein 4 (Bcl2-L-4);BAX;BCL2L4

4 kDa/12 kDa/15 kDa/18 kDa/19 kDa/21 kDa/24 kDa

20 kDa

1mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide,50% glycerol pH 7.4

Antigen Affinity Purification

Cancer;Cell Biology;Metabolism

Unconjugated

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2,and functions as an apoptotic activator. This protein is reported to interact with,and increase the opening of,the mitochondrial voltage-dependent anion channel (VDAC),which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants,which encode different isoforms,have been reported for this gene.