GSKIP Polyclonal Antibody

Verified Samples in IHC:Human cervical cancer

IHC 1:30-1:150

Polyclonal

IgG

Fusion protein of human GSKIP

GSKIP

C14ORF129;Chromosome 14 open reading frame 129 ;GSK3-beta interaction protein;GSK3beta interaction protein;GSKIP;GSKIP;MGC4945;UPF0279抗体

Cytoplasm.

0.78 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cell Biology

Unconjugated

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene.