GSTM1 Polyclonal Antibody

Verified Samples in WB:Rat heart
Verified Samples in IHC:Human kidney
Verified Samples in IF:NIH-3T3,C6

Polyclonal

IgG

Recombinant Mouse GSTM1 protein expressed by E.coli

GSTM1

Glutathione S-transferase Mu 1;EC:2.5.1.18;GST 1-1;GST class-mu 1;Glutathione S-transferase GT8.7;pmGT10;Gstm1

25kDa

26kDa

1mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide,50% glycerol pH 7.4

Antigen Affinity Purification

Unconjugated

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present,eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha,kappa,mu,omega,pi,sigma,theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds,including carcinogens,therapeutic drugs,environmental toxins and products of oxidative stress,by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers,likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.