IkB alpha Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
- 宿主: Rabbit
- 反应性: Human
- 应用性: IHC
Verified Samples |
Verified Samples in IHC:Human lung cancer,Human stomach cancer,Human colon cancer,Human prostate |
Dilution | IHC 1:200-1:800 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse IKBα |
Abbre | IkB alpha |
Synonyms | I kappa B alpha;I-kappa-B-alpha;IkappaBalpha;IkB-alpha;IKBA;IKBA;IKBalpha;MAD 3;MAD3;Major histocompatibility complex enhancer-binding protein MAD3;NF kappa B inhibitor alpha;NF-kappa-B inhibitor alpha;NFKBI;NFKBIA;Nuclear factor of kappa light chain gene enhancer in B cells;Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha抗体 |
Swissprot | |
Cellular Localization | Cytoplasm, Nucleus |
Concentration | 1.3 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer; Epigenetics and Nuclear Signaling; Immunology; Signal Transduction |
Conjugation | Unconjugated |
Background | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor,alpha (NFKBIA,synonyms: IKBA,MAD-3,NFKBI). NFKB1 or NFKB2 is bound to REL,RELA ,or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB),which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA,or IKBKB) marks them for destruction via the ubiquitination pathway,thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime. |
Immunohistochemistry analysis of paraffin-embedded human lung cancer using IkB alpha Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded human stomach cancer using IkB alpha Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded human colon cancer using IkB alpha Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded Human Prostate using IkB alpha Polyclonal Antibody(Elabscience Product Detected by Lifespan).
E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
E-IR-R304A | Western Blot Detection Kit | 50Assays |
E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |