(KO Validated) BAX Polyclonal Antibody

Verified Samples in WB:293T,293T,HeLa,Raji,RAW264.7,Mouse lung
Verified Samples in IHC:Rat ovary,Human lung cancer,Human breast cancer,Human stomach,Mouse liver,Mouse kidney

WB 1:500-1:2000, IHC 1:100-1:200

Polyclonal

IgG

A synthetic peptide of human BAX (NP_620116.1).

BAX

BCL2L4;BAX抗体

4kDa/12kDa/15kDa/18kDa/19kDa/21kDa/24kDa

20kDa

Cytoplasm and Mitochondrion membrane. Cytoplasm. Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.

1mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Affinity purification

Cancer; Cell Biology; Metabolism

Unconjugated

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.