MBL2/MBP-C Polyclonal Antibody

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- 宿主: Rabbit
- 反应性: Human;Mouse;Rat
- 应用性: WB
Verified Samples |
Verified Samples in WB: Human plasma, Human HepG2, Mouse liver, Mouse kidney, Rat kidney |
Dilution | WB 1:500-1:1000 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant Human MBL2/MBP-C protein expressed by E.coli |
Abbre | MBL2/MBP-C |
Synonyms | 2, COLEC 1, COLEC1, Collectin-1, HSMBPC, Lectin, Mannan binding lectin, Mannan binding protein, Mannan-binding protein, Mannose bindi, Mannose binding lectin (protein C) 2, Mannose binding lectin (protein C) 2 soluble, mannose-binding, soluble, soluble (opsonic defect) |
Swissprot | |
Calculated MW | 26 kDa |
Observed MW | 26 kDa |
Cellular Localization | Secreted |
Tissue Specificity | Plasma protein produced mainly in the liver. |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
Purification Method | Antigen Affinity Purification |
Research Areas | Cancer, Immunology |
Conjugation | Unconjugated |
Background | Mannose-binding Lectin (MBL) is an acute phase protein bearing to the family of collectins produced by the liver as a monomer that forms a triple helix. Once released in serum,it further polymerizes forming dimers to octamers. The degree of serum polymerization is critical for the biological activity of MBL. MBL has higher affinity to microbial polysaccharides or their glycoconjugates. MBL was shown earlier to bind cell surfaces of bacteria,fungi,protozoa and viruses and acts as an acute-phase plasma protein (APP) during infection and inflammation. MBL activates the lectin-complement pathway,promotes opsonophagocytosis and modulates inflammation. |
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