MTOR Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB
| Verified Samples |
Verified Samples in WB:Hela,A431,MCF-7,Mouse testis,Mouse liver,Mouse brain,Mouse testis,Mouse liver,Mouse brain |
| Dilution | WB 1:500-1:2000 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein corresponding to Mouse mTOR |
| Abbre | MTOR |
| Synonyms | dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1);FK506 binding protein 12 rapamycin associated protein 1;FK506 binding protein 12 rapamycin associated protein 2;FK506 binding protein 12 rapamycin complex associated protein 1;FK506-binding protein 12-rapamycin complex-associated protein 1;FKBP rapamycin associated protein;FKBP12 rapamycin complex associated protein;FKBP12-rapamycin complex-associated protein 1;FKBP12-rapamycin complex-associated protein;FLJ44809;FRAP;FRAP1;FRAP2;Mammalian target of rapamycin;Mechanistic target of rapamycin;mTOR;MTOR;OTTHUMP00000001983;RAFT1;Rapamycin and FKBP12 target 1;Rapamycin associated protein FRAP2;Rapamycin target protein 1;Rapamycin target protein;RAPT1;Serine/threonine-protein kinase mTOR |
| Swissprot | |
| Calculated MW | 289kDa |
| Observed MW | 289kDa |
| Cellular Localization | Endoplasmic reticulum membrane. Golgi apparatus membrane. Mitochondrion outer membrane. Lysosome. Cytoplasm. Nucleus>PML body. Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB. |
| Concentration | 0.8 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4 |
| Purification Method | Affinity purification |
| Research Areas | Cancer; Cell Biology; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism |
| Conjugation | Unconjugated |
| Background | MTOR, also named as FRAP1, FRAP, FRAP2 and RAPT1, belongs to the PI3/PI4-kinase family. MTOR is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. MTOR is Kinase subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. The antibody is specific to MTOR. |
Western Blot analysis of various samples using MTOR Polyclonal Antibody at dilution of 1:1000.
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Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo
IF: 6.162Journal：Cancers -
Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers
IF: 4.848Journal：Frontiers in Oncology -
Rutacecarpine Inhibits Angiogenesis by Targeting the VEGFR2 and VEGFR2-Mediated Akt/mTOR/p70s6k Signaling Pathway
IF: 3.098
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