NBR1 Monoclonal Antibody

Verified Samples in IHC:Rat lung
Verified Samples in IF:Rat spleen

IHC 1:50-300, IF 1:50-1:200

Monoclonal

IgG

Recombinant Protein of NBR1

NBR1

1A1 3B;1A13B;B box protein;Cell migration-inducing gene 19 protein;KIAA0049;M17S2;Membrane component chromosome 17 surface marker 2;Membrane component;chromosome 17;surface marker 2 (ovarian carcinoma antigen CA125);MIG 19;MIG19;Migration inducing protein 19;NBR 1;Nbr1;NBR1;autophagy cargo receptor;NBR1;Neighbor of BRCA1 gene 1;Neighbor of BRCA1 gene 1 protein;Next to BRCA1 gene 1 protein;Ovarian carcinoma antigen CA125;Protein 1A1-3B抗体

Cytoplasm. Cytoplasmic vesicle>autophagosome. Lysosome. Cytoplasm>myofibril>sarcomere>M line. In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Protein A purification

Cancer; Cell Biology

Clone:4C6

Unconjugated

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Inclusion Body Myositis and Synucleinopathy. Among its related pathways are Mitophagy - animal. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.