p21 Polyclonal Antibody

Verified Samples in IHC:Human tonsil,Rat kidney

IHC 1:200-1:800

Polyclonal

IgG

KLH conjugated Synthetic peptide corresponding to Mouse P21

p21

CAP20;CDK-interacting protein 1;CDKI;CDKN1;Cdkn1a;CDN1A;CIP1;Cyclin Dependent Kinase Inhibitor 1A;Cyclin-dependent kinase inhibitor 1;Cyclin-dependent kinase inhibitor 1A (P21);Cyclin-dependent kinase inhibitor 1A (p21;Cip1);DNA Synthesis Inhibitor;MDA-6;MDA6;Melanoma differentiation-associated protein 6;Melanoma differentiation-associated protein;p21;P21 protein;p21CIP1;p21Cip1/Waf1;p21WAF;PIC1;SDI1;SLC12A9;WAF1;Wild type p53 activated fragment 1 (WAF1);Wild type p53 activated fragment 1;Wildtype p53-activated fragment 1抗体

Cytoplasm, Nucleus

0.7 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Affinity purification

Cancer; Cell Biology; Epigenetics and Nuclear Signaling

Unconjugated

CDKN1A (p21,CIP1,WAF1),a cyclin-dependent kinase inhibitor,is necessary for proper control of the cell cycle and premature senescence. P21 is a cyclin-dependent kinase (CDK) inhibitor that suppresses proliferation by inhibiting CDK2 and CDK1 activity at the G1/S and G2/M transitions. P21 is a major mediator of p53 to induce cell cycle arrest in G1. p21 can interact with proliferating cell nuclear antigen (PCNA),and plays a regulatory role in S phase DNA replication and DNA damage repair. P21 was reported to be specifically cleaved by CASP3-like caspases,which thus leads to a dramatic activation of CDK2,and may be instrumental in the execution of apoptosis following caspase activation. Overexpression of p21 decreases the expression levels of cell cycle progression genes and upregulates senescence-inducing genes.