SEMA4D Polyclonal Antibody

Verified Samples in WB:SH-SY5Y,Mouse thymus,Rat thymus

Polyclonal

IgG

Recombinant Human SEMA4D protein expressed by Mammalian

SEMA4D

CD100;CD100 antigen;Coll 4;COLL4;Collapsin 4;Collapsin4;GR3;MSEMA;SEM4D;Sema 4d;SEMA J;Semacl2;SemaH;SEMAJ;A8;BB18;GR3

96kDa

120kDa-140kDa

1mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide,50% glycerol pH 7.4

Antigen Affinity Purification

Cancer;Immunology;Neuroscience

Unconjugated

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system,induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2,which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.