SNCA Polyclonal Antibody

Price:
- 宿主: Rabbit
- 反应性: Human;mouse;Rat
- 应用性: WB
Verified Samples |
Verified Samples in WB: SH-SY5Y, Mouse brain, Rat brain |
Dilution | WB 1:500-1:1000 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant Human SNCA protein expressed by E.coli |
Abbre | SNCA |
Synonyms | PARK1, NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, SNCA |
Swissprot | |
Calculated MW | 14 kDa |
Observed MW | 16 kDa |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
Purification Method | Antigen Affinity Purification |
Research Areas | Cancer, Neuroscience |
Conjugation | Unconjugated |
Background | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release.Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores.Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis.Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. |
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