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TIMP-2/TIMP2 Polyclonal Antibody

TIMP-2/TIMP2 Polyclonal Antibody
  • TIMP-2/TIMP2 Polyclonal Antibody
  • TIMP-2/TIMP2 Polyclonal Antibody

Price: ¥2100.00 ¥800.00

Size:
100 μL 25 μL
  • 宿主: Rabbit
  • 反应性: Human;Mouse;Rat
  • 应用性: WB
Verified Samples
Verified Samples in WB: Human Hela, Human SH-SY5Y, Human A431, Rat C6, Human U-20S, Mouse NIH-3T3
Dilution
WB 1:500-1:1000
Clonality
Polyclonal
Isotype
IgG
Immunogen
Recombinant Human TIMP-2/TIMP2 protein expressed by E.coli
Abbre
TIMP-2/TIMP2
Synonyms
CSC-21K, Metalloproteinase inhibitor 2, TIMP2, Tissue inhibitor of metalloproteinases 2 (TIMP-2)
Swissprot
Calculated MW
24 kDa
Observed MW
24 kDa
Cellular Localization
Secreted
Tissue Specificity
Down-regulated by TGFB1
Concentration
1 mg/mL
Storage
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer
PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4
Purification Method
Antigen Affinity Purification
Research Areas
Cancer, Cardiovascular, Cell Biology, Signal Transduction
Conjugation
Unconjugated
Background
Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family,TIMP-1,TIMP-2,TIMP-3,and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types,which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid-potentiating and cell growth promoting activities.
Western blot with TIMP-2/TIMP2 Polyclonal antibody at dilution of 1:1000.lane 1:Hela whole cell lysate,lane 2:SH-SY5Y whole cell lysate,lane 3:A431 whole cell lysate,lane 4:C6 whole cell lysate,lane 5:U-20S whole cell lysate,lane 6:NIH-3T3 whole cell lysate
E-AB-1003 Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) 500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043 Streptavidin(peroxidase/HRP conjugated) 500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1194 HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed 500 μL , 120 μL , 1 mL
E-IR-R304A Western Blot Detection Kit 50 Assays
E-IR-R304B High Accuracy and Absorbability Western Blot Detection Kit 50 Assays


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