TIMP-2/TIMP2 Polyclonal Antibody

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- 宿主: Rabbit
- 反应性: Human;Mouse;Rat
- 应用性: WB
Verified Samples |
Verified Samples in WB: Human Hela, Human SH-SY5Y, Human A431, Rat C6, Human U-20S, Mouse NIH-3T3 |
Dilution | WB 1:500-1:1000 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant Human TIMP-2/TIMP2 protein expressed by E.coli |
Abbre | TIMP-2/TIMP2 |
Synonyms | CSC-21K, Metalloproteinase inhibitor 2, TIMP2, Tissue inhibitor of metalloproteinases 2 (TIMP-2) |
Swissprot | |
Calculated MW | 24 kDa |
Observed MW | 24 kDa |
Cellular Localization | Secreted |
Tissue Specificity | Down-regulated by TGFB1 |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
Purification Method | Antigen Affinity Purification |
Research Areas | Cancer, Cardiovascular, Cell Biology, Signal Transduction |
Conjugation | Unconjugated |
Background | Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family,TIMP-1,TIMP-2,TIMP-3,and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types,which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid-potentiating and cell growth promoting activities. |
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Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts
IF: 3.365Journal: WORLD JOURNAL OF GASTROENTEROLOGY (2017)PMID:29358859Reactivity:HumanSample Type:Cell lysate
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E-IR-R304A | Western Blot Detection Kit | 50 Assays |
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