AMIGO2 Polyclonal Antibody

Verified Samples in WB:SP20,Mouse heart
Verified Samples in IHC:Human esophagus cancer,Human breast cancer

WB 1:500-1:2000;IHC 1:50-1:200

Polyclonal

IgG

Recombinant protein of human AMIGO2

AMIGO2

Adhesion molecule with Ig like domain 2;ALI 1;ALI1;Alivin 1;Alivin-1;Alivin1;AMGO2;AMIGO 2;AMIGO-2;Amigo2;Amphoterin induced gene 2;Amphoterin induced protein 2;Amphoterin-induced gene and open reading frame 2;Amphoterin-induced protein 2;DEGA;Differentially expressed in gastric adenocarcinoma;Differentially expressed in gastric adenocarcinomas;Transmembrane protein AMIGO 2;Transmembrane protein AMIGO2抗体

58kDa

Cell membrane. Nucleus. Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons.

0.5 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Neuroscience

Unconjugated

The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction