CASP1 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主： Rabbit
- 反应性： Human
- 应用性： WB;IHC
| Verified Samples |
Verified Samples in WB:Hela Verified Samples in IHC:Human pancreatic cancer |
| Dilution | WB 1:1000-1:4000;IHC 1:25-1:100 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Fusion protein of human CASP1 |
| Abbre | CASP1 |
| Synonyms | CASP-1;CASP1;CASP1;Caspase 1;Caspase-1 subunit p10;ICE;IL-1 beta-converting enzyme;IL-1BC;IL1 beta converting enzyme;IL1B convertase;Interleukin 1 beta convertase;Interleukin 1B converting enzyme;Interleukin-1 beta convertase;Interleukin-1 beta-converting enzyme;p45抗体 |
| Swissprot | |
| Calculated MW | 45 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cytoplasm. |
| Concentration | 0.4 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer; Cell Biology; Metabolism |
| Conjugation | Unconjugated |
| Background | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. |
Western blot analysis of Hela cells using CASP1 Polyclonal Antibody at dilution of 1:1000
Immunohistochemistry of paraffin-embedded Human pancre at ic cancer tissue using CASP1 Polyclonal Antibody at dilution of 1:25(×200)
| E-AB-1003 | Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500μL , 120μL , 1mL |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
| E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
| E-IR-R304A | Western Blot Detection Kit | 50Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |
