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CCDC88A Polyclonal Antibody

Price: ¥2365 ¥1640 ¥1010 ¥420

Size:
200μL 120μL 60μL 20μL
  • 宿主: Rabbit
  • 反应性: Human;Mouse
  • 应用性: IHC
Verified Samples
Verified Samples in IHC:Human cervical cancer,Human colon cancer
Dilution
IHC 1:50-1:200
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthetic peptide of human CCDC88A
Abbre
CCDC88A
Synonyms
AKT iphosphorylation enhancer;Akt phosphorylation enhancer;APE;Ccdc88a;Coiled coil domain containing 88A;Coiled coil domain containing protein 88A;Coiled-coil domain-containing protein 88A;FLJ10392;G alpha interacting vesicle associated protein;G alpha-interacting vesicle-associated protein;Galpha interacting vesicle associated protein;Girders of actin filament;Girdin;GIV;GRDN;GRDN;HkRP1;Hook related protein 1;Hook-related protein 1;KIAA1212
Swissprot
Cellular Localization
Membrane. Cell membrane. Cytoplasm>cytosol. Cytoplasmic vesicle. Cell projection>lamellipodium. Localizes to the cell membrane through interaction with phosphoinositides.
Concentration
1 mg/mL
Storage
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method
Affinity purification
Research Areas
Cancer; Neuroscience; Signal Transduction
Conjugation
Unconjugated
Background
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CCDC88A Polyclonal Antibody at dilution 1:50
Immunohistochemistry of paraffin-embedded Human colon cancer tissue using CCDC88A Polyclonal Antibody at dilution 1:50


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