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CD59 Polyclonal Antibody

Price: ¥2365 ¥1640 ¥1010 ¥420

Size:
200μL 120μL 60μL 20μL
  • 宿主: Rabbit
  • 反应性: Human
  • 应用性: IHC
Verified Samples
Verified Samples in IHC:Human liver cancer
Dilution
IHC 1:200-1:300
Clonality
Polyclonal
Isotype
IgG
Immunogen
Fusion protein of human CD59
Abbre
CD59
Synonyms
16.3A5;1F5;1F5 antigen;20 kDa homologous restriction factor;CD 59;CD_antigen=CD59;CD59;CD59 antigen;CD59 antigen complement regulatory protein ;CD59 antigen p18 20;CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5;EJ16;EJ30;EL32 and G344);CD59 glycoprotein;CD59 molecule;CD59 molecule complement regulatory protein;CD59;Cd59a;Complement regulatory protein;EJ16;EJ30;EL32;FLJ38134;FLJ92039;G344;HRF 20;HRF-20;HRF20;Human leukocyte antigen MIC11;Ly 6 like protein;Lymphocytic antigen CD59/MEM43;MAC inhibitory protein;MAC IP;MAC-inhibitory protein;MAC-IP;MACIF;MACIP;MEM43;MEM43 antigen;Membrane attack complex (MAC) inhibition factor;Membrane attack complex inhibition factor;Membrane inhibitor of reactive lysis;MGC2354;MIC11;MIN1;MIN2;MIN3;MIRL;MSK21;p18 20;Protectin;Surface antigen recognized by monoclonal 16.3A5;T cell activating protein
Swissprot
Cellular Localization
Cell membrane. Secreted. Soluble form found in a number of tissues.
Concentration
1.38 mg/mL
Storage
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Purification Method
Antigen affinity purification
Research Areas
Cancer; Cardiovascular; Immunology; Signal Transduction; Stem Cells
Conjugation
Unconjugated
Background
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction.


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