CDKN1B Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主: Rabbit
- 反应性: Human; Mouse
- 应用性: IHC
Verified Samples |
Verified Samples in IHC:Human cervical cancer,Human ovarian cancer |
Dilution | IHC 1:50-1:300 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Fusion protein of human CDKN1B |
Abbre | CDKN1B |
Synonyms | AA408329;AI843786;Cdki1b;CDKN 1B;CDKN 4;CDKN1B;CDKN4;CDN1B;Cyclin Dependent Kinase Inhibitor 1B;Cyclin dependent kinase inhibitor p27;Cyclin-dependent kinase inhibitor 1B (p27;Kip1);Cyclin-dependent kinase inhibitor 1B;Cyclin-dependent kinase inhibitor p27;Cyclin-dependent kinase inhibitor p27 Kip1;KIP 1;KIP1;MEN1B;MEN4;OTTHUMP00000195098;OTTHUMP00000195099;p27;p27 Kip1;P27-like cyclin-dependent kinase inhibitor;p27Kip1 |
Swissprot | |
Cellular Localization | Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells. AKT-or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6 and this leads to lysosomal degradation. |
Concentration | 1.32 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
Purification Method | Antigen affinity purification |
Research Areas | Cancer; Cell Biology; Epigenetics and Nuclear Signaling |
Conjugation | Unconjugated |
Background | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). |
Immunohistochemistry of paraffin-embedded Human cervical cancer tissueusing CDKN1B Polyclonal Antibody at dilution of 1:75(×200)
Immunohistochemistry of paraffin-embedded Human ovarian cancer tissueusing CDKN1B Polyclonal Antibody at dilution of 1:75(×200)
E-AB-1003 | Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500μL , 120μL , 1mL |
E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
E-IR-R304A | Western Blot Detection Kit | 50Assays |
E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |