HLA-C Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主： Rabbit
- 反应性： Human
- 应用性： IHC
| Verified Samples |
Verified Samples in IHC:Human colorectal cancer,Human cervical cancer |
| Dilution | IHC 1:25-1:100 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthetic peptide of human HLA-C |
| Abbre | HLA-C |
| Synonyms | HLA-JY3;D6S204;HLAC;Psoriasis Susceptibility 1;HLA-C Alpha Chain;PSORS1;MHC抗体 |
| Swissprot | |
| Cellular Localization | Membrane, MHC I |
| Concentration | 0.66 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Purification Method | Antigen affinity purification |
| Research Areas | Immunology;Microbiology |
| Conjugation | Unconjugated |
| Background | HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described . |
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using HLA-C Polyclonal Antibody at dilution of 1:25(×200)
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using HLA-C Polyclonal Antibody at dilution of 1:25(×200)
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Functional HLA-C expressing trophoblast spheroids as a model to study placental–maternal immune interactions during human implantation
IF: 4.38Journal：Scientific Reports
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