IDO1 Polyclonal Antibody
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- 宿主： Rabbit
- 反应性： Human
- 应用性： IHC
| Verified Samples |
Verified Samples in IHC: Human tonsil |
| Dilution | IHC 1:150-1:300 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant Human IDO1 protein expressed by E.coli |
| Abbre | IDO1 |
| Synonyms | 3-dioxygenase, 3-dioxygenase 1, IDO, IDO-1, IDO1, INDO, Indole 2, Indoleamine 2 |
| Swissprot | |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cardiovascular, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Background | Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant,essential amino acid,l-tryptophan,along the kynurenine pathway. This protein is normally expressed in the dendritic cells,macrophages,microglia,eosinophils,fibroblasts,endothelial cells,and most tumor cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer,chronic viral infections,and other diseases characterized by pathological immune suppression. |
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