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IkB alpha Polyclonal Antibody

Price: ¥2365 ¥1640 ¥1010 ¥420

Size:
200μL 120μL 60μL 20μL
  • 宿主: Rabbit
  • 反应性: Rat
  • 应用性: IHC
Verified Samples
Verified Samples in IHC:Rat kidney
Dilution
IHC 1:50-1:100
Clonality
Polyclonal
Isotype
IgG
Immunogen
Recombinant Rat NF-kappa-B inhibitor alpha protein
Abbre
NFKBIA
Synonyms
I kappa B alpha;I-kappa-B-alpha;IkappaBalpha;IkB-alpha;IKBA;IKBA;IKBalpha;MAD 3;MAD3;NF kappa B inhibitor alpha;NFKBI;IKB alpha抗体
Swissprot
Cellular Localization
Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Concentration
2mg/mL
Storage
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method
Affinity purification
Research Areas
Cancer; Epigenetics and Nuclear Signaling; Immunology; Signal transduction
Conjugation
Unconjugated
Background
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Immunohistochemistry of paraffin-embedded Rat kidney using IkB alpha Polyclonal Antibody at dilution of 1:50


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