LRP6 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主: Rabbit
- 反应性: Human;Mouse
- 应用性: IHC
Verified Samples |
Verified Samples in IHC:Human liver cancer |
Dilution | IHC 1:40-200 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Synthetic peptide of human LRP6 |
Abbre | LRP6 |
Synonyms | ADCAD2;C030016K15Rik;Cd;FLJ90062;FLJ90421;LDL receptor related protein 6;Low density lipoprotein receptor related protein 6;Low-density lipoprotein receptor-related protein 6;LRP-6;LRP6;LRP6;OTTHUMP00000238979;OTTHUMP00000238980;OTTHUMP00000238982;STHAG7抗体 |
Swissprot | |
Cellular Localization | Membrane. Endoplasmic reticulum. On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD. |
Concentration | 1.4 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer; Signal transduction; Stem cells |
Conjugation | Unconjugated |
Background | This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. |
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using LRP6 Polyclonal Antibody at dilution 1:60
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Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis
IF: 4.416
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E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |