p27 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
- 宿主： Rabbit
- 反应性： Human;Rat
- 应用性： IHC
| Verified Samples |
Verified Samples in IHC:Human lung cancer,Human liver cancer,Rat spleen cancer,Human prostate |
| Dilution | IHC 1:100-1:400 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse P27 KIP1 |
| Abbre | p27 |
| Synonyms | AA408329;AI843786;Cdki1b;CDKN 1B;CDKN 4;CDKN1B;CDKN4;CDN1B;Cyclin Dependent Kinase Inhibitor 1B;Cyclin dependent kinase inhibitor p27;Cyclin-dependent kinase inhibitor 1B (p27;Kip1);Cyclin-dependent kinase inhibitor 1B;Cyclin-dependent kinase inhibitor p27;Cyclin-dependent kinase inhibitor p27 Kip1;KIP 1;KIP1;MEN1B;MEN4;OTTHUMP00000195098;OTTHUMP00000195099;p27;p27 Kip1;P27-like cyclin-dependent kinase inhibitor;p27Kip1 |
| Swissprot | |
| Cellular Localization | Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells. AKT-or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6 and this leads to lysosomal degradation. |
| Concentration | 0.89 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4 |
| Purification Method | Affinity purification |
| Research Areas | Cancer; Cell Biology; Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Background | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). |
Immunohistochemistry analysis of paraffin-embedded human lung cancer using p27 Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded human liver cancer using p27 Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded Rat spleen cancer using p27 Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded Human Prostate using p27 Polyclonal Antibody(Elabscience Product Detected by Lifespan).
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