CD4 Monoclonal Antibody
Price:
Size:
120μL
60μL
20μL
- 宿主： Mouse
- 反应性： Human;Mouse;Rat
- 应用性： IHC-p;IF
| Verified Samples |
Verified Samples in IHC:Human stomach,Mouse brain Verified Samples in IF:Mouse colonic |
| Dilution | IHC 1:100-1:300;IF 1:50-200 |
| Clonality | Monoclonal |
| Isotype | IgG |
| Immunogen | Synthetic Peptide |
| Abbre | CD4 |
| Synonyms | CD 4;CD4 (L3T4);CD4;CD4 antigen (p55);CD4 antigen;CD4 molecule;CD4 receptor;CD4+ Lymphocyte deficiency;included;CD4;CD4mut;L3T4;Leu3;Ly-4;Lymphocyte antigen CD4;MGC165891;OTTHUMP00000238897;p55;T cell antigen T4;T cell antigen T4/LEU3;T cell differentiation antigen L3T4;T cell OKT4 deficiency;included;T cell surface antigen T4/Leu 3;T cell surface antigen T4/Leu3;T cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4;W3/25;W3/25 antigen抗体 |
| Swissprot | |
| Cellular Localization | Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. |
| Tissue Specificity | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
| Purification Method | Protein A purification |
| Research Areas | Cancer; Immunology; Stem Cells |
| Clone No. | Clone:9G1 |
| Conjugation | Unconjugated |
| Background | This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |
Immunohistochemistry of paraffin-embedded Human stomach tissue using CD4 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Mouse brain tissue using CD4 Monoclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Mouse colonic tissue with CD4 Monoclonal Antibody.
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Sexual dimorphism in Th17/Treg axis in lymph nodes draining inflamed joints in rats with collagen-induced arthritis
IF: 6.306 -
Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation
IF: 6.304Journal：Cell Death & Disease
