CASP4 Polyclonal Antibody

Verified Samples in IHC:Human tonsil,Human colon
Verified Samples in IF:Mouse NIH-3T3

IHC 1:400-1:800;IF 1:50-1:200

Polyclonal

IgG

Recombinant Human CASP4 protein expressed by E.coli

CASP4

Apoptotic cysteine protease Mih1/TX;CASP-4;CASP4;CASP4;Caspase 4 apoptosis related cysteine peptidase;Caspase-4 subunit 2;Caspase4;ICE(rel)-II;ICE(rel)II;ICEREL II;ICH2;Mih1/TX;Protease ICH-2;Protease TX;TX

Cytosol;AIM2 inflammasome complex;cytosol;IPAF inflammasome complex;NLRP3 inflammasome complex;Endoplasmic reticulum;endoplasmic reticulum;endoplasmic reticulum membrane;Extracellular region or secreted;extracellular region;Mitochondrion;Plasma Membrane;Other locations:protein complex

1mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Cancer; Cell Biology; Metabolism

Unconjugated

This gene encodes a member of the cysteine proteases that plays important roles in apoptosis,cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4,apoptosis-related cysteine peptidase",this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.