CASP4 Polyclonal Antibody

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- 宿主: Rabbit
- 反应性: Human;Mouse
- 应用性: IHC;IF
Verified Samples |
Verified Samples in IHC: Human tonsil, Human colon Verified Samples in IF: Mouse NIH-3T3 |
Dilution | IHC 1:400-1:800, IF 1:50-1:200 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant Human CASP4 protein expressed by E.coli |
Abbre | CASP4 |
Synonyms | Apoptotic cysteine protease Mih1/TX, CASP-4, CASP4, Caspase 4 apoptosis related cysteine peptidase, Caspase-4 subunit 2, Caspase4, ICE(rel)-II, ICE(rel)II, ICEREL II, ICH2, Mih1/TX, Protease ICH-2, Protease TX, TX |
Swissprot | |
Cellular Localization | Cytosol, AIM2 inflammasome complex, cytosol, IPAF inflammasome complex, NLRP3 inflammasome complex, Endoplasmic reticulum, endoplasmic reticulum, endoplasmic reticulum membrane, Extracellular region or secreted, extracellular region, Mitochondrion, Plasma Membrane, Other locations: protein complex. |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
Purification Method | Antigen Affinity Purification |
Research Areas | Cancer, Cell Biology, Metabolism |
Conjugation | Unconjugated |
Background | This gene encodes a member of the cysteine proteases that plays important roles in apoptosis,cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4,apoptosis-related cysteine peptidase",this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. |