Cleaved-CASP3 p17 (D175) Polyclonal Antibody

Verified Samples in WB:Hela,Mouse samples,Rat heart,Recombinant protein,Rat lung,Rat lung,Rat brain,Mouse colon,Mouse kidney
Verified Samples in IHC:Human stomach cancer
Verified Samples in IF:Rat liver

WB 1:500-2000;IHC 1:50-300;IF 1:50-300

Polyclonal

IgG

Synthesized peptide derived from the Internal region of human Caspase-3 p17

Cleaved-Caspase-3 p17 (D175)

A830040C14Rik;Apopain;CASP-3;CASP3;CASP3;Casp3a;Caspase 3;Caspase 3;apoptosis-related cysteine peptidase;Caspase 3;apoptosis-related cysteine protease;Caspase 3;apoptosis-related cysteine protease a;Caspase-3 subunit p12;CC3;CPP-32;CPP32;CPP32B;Cysteine protease CPP32;EC 3.4.22.56;LICE;mldy;OTTHUMP00000165052;OTTHUMP00000165053;OTTHUMP00000165054;PARP cleavage protease;Procaspase3;Protein Yama;SCA 1;SCA-1;SREBP cleavage activity 1;Yama抗体

32kDa

20kDa

Cytoplasm.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Affinity purification

Cancer; Cell Biology; Metabolism; Neuroscience

Unconjugated

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.