LMNA Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB;IHC-p;IF
| Verified Samples |
Verified Samples in WB:3T3 Verified Samples in IHC:Human uterus Verified Samples in IF:Human liver |
| Dilution | WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human Lamin A/C around the non-phosphorylation site of Ser392. |
| Abbre | Lamin A/C |
| Synonyms | 70 kDa lamin;Cardiomyopathy dilated 1A (autosomal dominant);CDCD1;CDDC;CMD1A;CMT2B1;EMD2;FPL;FPLD;FPLD2;HGPS;IDC;Lamin A;Lamin A/C;Lamin A/C like 1;Lamin;Lamin C;Lamin-A/C;LDP1;LFP;LGMD1B;Limb girdle muscular dystrophy 1B (autosomal dominant);LMN 1;LMN A;LMN C;LMN1;LMNA;LMNA;LMNC;LMNL1;Prelamin A/C;PRO1;Renal carcinoma antigen NY REN 32;Renal carcinoma antigen NY-REN-32;Renal carcinoma antigen NYREN32抗体 |
| Swissprot | |
| Calculated MW | 74kDa |
| Observed MW | 74kDa,65kDa |
| Cellular Localization | Nucleus. Nucleus envelope. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C. |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4 |
| Purification Method | Affinity purification |
| Research Areas | Cancer; Signal Transduction; Tags and Cell Markers |
| Conjugation | Unconjugated |
| Background | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. |
Western Blot analysis of 3T3 cells using LMNA Polyclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded Human uterus tissue using LMNA Polyclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Human liver tissue using LMNA Polyclonal Antibody at dilution of 1:200.
